Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene.[1] TLR8 has also been designated as CD288 (cluster of differentiation 288).
Contents |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.[2]
TLR8 recognises G-rich oligonucleotides.[3]
Genetics variants in TLR8 has recently been linked to susceptibility to pulmonary tuberculosis.[4]
|
|||||||||||||||||||||||
|
||||||||||||||